A number of things are done to try and reduce the rate of nephron loss as a result of hyperfiltration injury.
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In the face of loss of nephron mass, the kidney tries to maintain function by increasing the work of the remaining nephrons. This increase in individual nephron GFR is achieved by increasing the glomerular capillary pressure and this ultimately leads to further nephron loss and a down-hill spiral in renal function. Progression is perpetuated by all factors that contribute to the increase in single nephron GFR and glomerular pressure, particularly by hypertension and high dietary protein load.