Metabolic alkalosis correctable by chloride and ECF volume replacement

This is usually the result of selective chloride loss from the body, either from the gut or the kidneys.  This is accompanied by volume depletion which via the effects of aldosterone on the distal tubule leads to potassium loss and hypokalaemia.

The two commonest causes are:

• Loss of gastric fluid through vomiting or nasogastric suction

• Use of diuretics

Back