Apparent mineralocorticoid excess syndromes
A number of hereditary abnormalities affecting the distal
tubule mimic mineralocorticoid excess:
-
Loss of the ability to down-regulate the Na+
channel in the cortical collecting duct (Liddle's syndrome).
-
A defect leading to inactivation of an enzyme associated
with the aldosterone receptor, resulting in the receptor being activated by
cortisol as well as aldosterone.
These conditions are characterised by a very low aldosterone level.
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